S&P 500 7,520.93 YTD +9.87% Week −0.63% As of 10 Nov 2026 Latest letter Issue 1: Flows, Not Fundamentals →

In depth

Company research

The letter gives each trade in brief. Here is the complete analysis behind it: the business, the data, the competition, the risks and why we think the price is wrong.

CMPS Compass Pathways
Biotech · Psychiatry

COMP360: works, reproducibly but modestly. The edge is burden and first-mover timing.

A full read of the COMP360 psilocybin programme for treatment-resistant depression: the drug, both Phase 3 trials, every efficacy timepoint and p-value, safety, competitors, the FDA's psychedelic guidance and what the market is missing.

Phase 3 patients
839
Primary endpoint gap (MADRS)
−3.6 / −3.8
Expected FDA decision
~mid-Jan 2027
Cash vs. debt
$433M / $51M

10 November 202618 min readFrom Issue 1